Modeling of Drug Delivery by A Pump Driven Micro-Needle Array System

BACKGROUND Micro-needles were proposed as one of the alternatives to deliver drugs painlessly passing through stratum corneum in recent years. In this work, a mathematical model is presented to characterize the in fusion flow of a hollow micro-needle array driven by a micro-pump. METHODS By assuming the injection of each micro-needle undergoes a spherical expansion and diffusion, the model is able to calculate the time-varying expansion radius, and the diffusion boundary, provided that the material properties and the micro-needle system parameters are known. RESULTS AND CONCLUSION The calculation results show that the expansion caused by the infusion of micro-needles stops and the flow rate drops to zero in a short time. However, the diffusion boundary is much bigger than the expansion and the infusion continues if the surrounding material is absorptive. The experimental results of jet infusion through a single needle in silicon rubber and polyacrylamide gel agree with the calculation results qualitatively.